Exosomes

Extracellular vesicles (EVs) were first discovered over 50 years ago in plasma. All cells and biological fluids contain these mini “packets” of information that are absolutely essential for the body to function on a daily basis. There are 3 main types of EVs, each with a very different size and essential function: microparticles, apoptotic bodies, and most compelling, exosomes. 

Exosomes are incredible messenger packets that are responsible for cell-cell communication, survival, and maintaining cellular health and extracellular integrity. While they are only 1/1000th the size of a cell, exosomes act as cargos that deliver crucial information from one cell to another. In order to maintain a healthy physiological environment, exosomes are produced within cells and released for use by neighboring cells or for production of any needed proteins within the environment (collagen, growth factors, chemical messengers, and more). Following release from a cell, the cargo is delivered to either the extracellular matrix or to neighboring cells to fuse with and deliver important information. Interestingly, exosomes have a similar lipid membrane composition to cells, which serves as a protection mechanism when they are released from inside the cell.

Perhaps one of the most fascinating elements of exosomes is their ability to secrete in higher abundance when cells are stressed. Exosomes act as the body’s natural healing response to a problem that needs to be corrected, which is why these incredible messenger packets are revolutionizing the regenerative medicine sector. 

Exosome therapy has been shown to provide several benefits, including tissue repair and regeneration, reduced inflammation, enhanced immune system, improved neurological function, enhanced skin health, and overall wellness promotion.

Studies have demonstrated that exosomes contain various molecules, such as growth factors, cytokines, and enzymes, that can stimulate tissue repair and regeneration1-2. Additionally, exosomes have anti-inflammatory properties, which can help reduce pain, swelling, and other symptoms of inflammation-related conditions3. Furthermore, exosomes have been shown to enhance the activity of immune cells, which can help fight off infections and diseases4.

Exosome therapy can also promote nerve cell growth and survival, which may help improve neurological function in people with conditions like Parkinson’s or Alzheimer’s disease5. Moreover, exosomes can improve skin health by promoting collagen production, which can help reduce the appearance of fine lines and wrinkles6.

Additionally, exosome IV therapy can help improve overall wellness by promoting cellular health, reducing inflammation, and enhancing the body’s natural healing mechanisms7.

Exosomes can be isolated from stem cells and other tissues known to have regenerative properties. Moreover, it is well understood that adult stem cells act in a paracrine manner, meaning they secrete exosomes and proteins that affect neighboring cells to heal and repair. Therefore, these cargo packets can be isolated from stem cells and delivered to sites of interest to initiate healing. Imagine treating conditions within your body at the cellular level. 

At REHEALTH, we use the gold-standard of exosomes isolated from young umbilical cord mesenchymal stem cells that have been grown in a proprietary method to create a more potent product. This method has been studied for over 9 years to ensure we provide the best and safest product that has properties for healing and repair. We believe the most essential way to repair your body’s healthspan is at the cellular level. 

See if REHEALTH is Right for You

At REHEALTH, our mission is to improve patient health and well-being through precision stem cell therapeutics. Our team of certified physicians will work with you to design a personalized therapeutic approach to target your specific needs. 

Join thousands of other patients who have experienced relief they never thought was possible. Schedule a free discovery call and start your journey to recovery today.

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References

  1. Haraszti, R. A., Didiot, M. C., Sapp, E., Leszyk, J., Shaffer, S. A., Rockwell, H. E., … & Khvorova, A. (2016). High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. Journal of extracellular vesicles, 5(1), 1-22.
  2. Chen, L., & Wang, Y. (2020). Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer’s Disease. Mediators of inflammation, 2020.
  3. Wiklander, O. P., Nordin, J. Z., O’Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., … & Vader, P. (2015). Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. Journal of extracellular vesicles, 4(1), 1-13.
  4. Liang, X., Zhang, L., Wang, S., Han, Q., Zhao, R. C., & Wu, Y. (2014). Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives. Cell transplantation, 23(9), 1045-1059.
  5. Bahrini, I., Song, J. H., Diez, D., & Hanayama, R. (2021). Neuronally Derived Extracellular Vesicles: An Emerging Mechanism of Cellular Communication in the Nervous System. International journal of molecular sciences, 22(10), 5093.
  6. Tsioumas, G., Chaitidis, P., Koutsopoulos, A. V., & Michalopoulos, E. (2021). The effects of extracellular vesicles on skin ageing. Journal of drug targeting, 1-9.
  7. Yin, K., Zhang, J., & Chen, W. (2019). Mechanisms involved in the therapeutic effects of exosomes derived from mesenchymal stem cells on myocardial infarction. Stem cell research & therapy, 10(1), 1-